A case of cryptic acute promyelocytic leukemia
نویسندگان
چکیده
منابع مشابه
FISH-negative, cytogenetically cryptic acute promyelocytic leukemia
Approximately 600–800 new cases of acute promyelocytic leukemia (APL) occur annually in the United States. The advent of all-trans retinoic acid (ATRA) has converted this subtype of acute leukemia to a readily curable one with excellent long-term outcomes. Rapid diagnosis and immediate treatment is crucial in APL and a requirement for favorable prognosis. t(15;17)(q24;q21) is the characteristic...
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Splenic infarction occurs due to occlusion of splenic vessels that leads to splenic tissue ischemia and necrosis. There are several reports regarding splenic infarction in patients with acute myelogenous leukemia (AML). Herein, we report a case of acute promyelocytic anemia (AML-M3) who presented with abdominal pain and splenic infarction.
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BACKGROUND The recent study described a better outcome in acute promyelocytic leukemia patients treated with all-trans retinoic acid and arsenic oxide compared to those treated with all-trans retinoic acid combined with conventional chemotherapy. The pivotal study indicated that favorable-risk acute promyelocytic leukemia patients can be cured without any cytotoxic chemotherapy. Even high-risk ...
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Acute leukemia is often associated with oral manifestations. We report an acute promyelocytic leukemia (APL) case with oral manifestations leading to the diagnosis. A 21-year-old female visited our hospital with complaints of gingival bleeding and swelling of the left lower wisdom tooth. The patient’s complete blood count revealed a marked increase in white blood cells and a decrease in red blo...
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Several variant RARA translocations have been reported in acute promyelocytic leukemia (APL) of which the t(11;17)(q23;q21), which results in a ZBTB16-RARA fusion, is the most widely identified and is largely resistant to therapy with all-trans retinoic acid (ATRA). The clinical course together with the cytogenetic and molecular characterization of a case of ATRA-unresponsive ZBTB16-RARA APL is...
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ژورنال
عنوان ژورنال: Leukemia
سال: 1998
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2401094